The development of a plant-based vaccine for measles
Identifieur interne : 00A399 ( Main/Exploration ); précédent : 00A398; suivant : 00A400The development of a plant-based vaccine for measles
Auteurs : D. E. Webster [Australie] ; M. C. Thomas [Australie] ; Z. Huang [Australie] ; S. L. Wesselingh [Australie]Source :
- Vaccine [ 0264-410X ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccin, Vaccination.
English descriptors
- KwdEn :
Abstract
Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Plant-based vaccination strategies have the potential to overcome the limitations of the current measles vaccine. The measles virus hemagglutinin (MV-H) protein has been expressed in tobacco. Oral immunisation of mice with plant-derived MV-H protein resulted in MV-specific antibodies and secretory IgA, indicative of humoral and mucosal immune responses. In addition, boosting with oral plant-derived MV-H protein following a MV-H DNA prime, resulted in a greater response than could be induced with either vaccine alone. Collectively, this research represents a significant step towards an effective oral measles vaccine that would be temperature-stable, easy to administer and amenable to inexpensive manufacture.</div>
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<tree><country name="Australie"><noRegion><name sortKey="Webster, D E" sort="Webster, D E" uniqKey="Webster D" first="D. E." last="Webster">D. E. Webster</name>
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<name sortKey="Huang, Z" sort="Huang, Z" uniqKey="Huang Z" first="Z." last="Huang">Z. Huang</name>
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